Spravato® Esketamine Therapy

What Is Esketamine Therapy? Esketamine therapy involves the clinically supervised use of Esketamine to treat mental health conditions. Esketamine is a drug that has been traditionally used for anesthesia, but in recent years, has proven to be a viable treatment for a variety of conditions, including: Anxiety, Depression, OCD, and PTSD.

How Does Esketamine Therapy Work?

Esketamine binds to specific receptors in the brain and activates and enhances the connections between neurons. This helps neurons communicate in new ways, changing thought patterns, mood, and cognition.

During a treatment, Esketamine is administered via infusion (IV) or through a nasal spray, esketamine. Bloom provides both Esketamine infusions in our health centers.

How to Get Started with Ketamine Therapy

Esketamine therapy involves a series of treatments that taper down over the course of a few weeks or months. A typical session involves the administration of Esketamine followed by a monitoring period, where clinicians keep track of a patient’s vital signs to ensure safety.

Each session requires a two-hour appointment, and patients cannot drive or work for the rest of the day after receiving treatment. The treatment protocol is the same for patients receiving infusions or nasal spray.

Because Esketamine therapy can treat a variety of conditions, the best first step is to talk to your provider to see if you are a good candidate. You can request an appointment with our providers or take the screener to get started.


What is Esketamine?

Esketamine is a nasal-spray medication that is a treatment for depression. Combined with an antidepressant, Esketamine is FDA-approved to treat depression and has been clinically shown to improve symptoms of depression over just 4 weeks. Call the Patient Care Center at our main number to schedule a free consultation and see if Esketamine therapy is right for you.

What should I expect during treatment?
For the first month your esketamine treatment is twice weekly for 30 days, then once weekly for 30 days; thereafter, it can be once weekly or every two (2) weeks for maintenance. However, this is dependent on your individual treatment plan that your doctor will provide for you. You’ll need to plan for rides to and from the office for your treatment. Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep. To monitor for any adverse side effects, we will monitor you for two hours following treatment. Some patients taking Esketamine may experience nausea; you should not eat or drink 4 hours prior to treatment.
Is Esketamine therapy effective treatment for depression?
In clinical studies involving short- and long-term trials across more than 1700 adult patients, improvement of depressive symptoms was demonstrated at four weeks by Esketamine treatment plus an oral antidepressant, compared with placebo nasal spray plus an oral antidepressant. These studies evaluated the efficacy and safety of Esketamine, both short-term and long-term for up to one year, for treatment‑resistant depression.

Have questions?

We’re here to answer them. Give us a call or request an appointment through our online form.