Depression Management: Spravato® Esketamine Versus TMS – Which One is Right for You?

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Depression is a complex mental health disorder that affects millions of people all over the world. Symptoms range from feeling sadness, emptiness, and hopelessness, to appetite and weight changes, and in the worst cases, suicidal thoughts. According to the World Health Organization, 280 million individuals suffer from this disorder, making it one of the most widespread illnesses.

The Complexity of Depression and Its Various Causes

The symptoms of depression can range from mild to severe, varying in duration and intensity, but the consequences are always equally concerning. Signs that someone might be dealing with depression include long-lasting sadness and a lack of interest in previously pleasurable activities, changes in sleep or eating habits, and even suicidal ideas. The underlying cause of depression may be various, including major depressive disorder (MDD), persistent depressive disorder, postpartum depression, bipolar disorder, and seasonal affective disorder (SAD). Also, particular medications, substance use, and medical issues may lead to depression. It is essential to have a professional evaluation to discover the origin and come up with a suitable treatment plan.

When Traditional Depression Treatment Approaches Fall Short: The Need for Innovative Solutions

For some individuals, traditional approaches like therapy and antidepressants may not work for depression. Studies show that 50% to 66% of depressed patients do not respond to antidepressants, and each subsequent medication trial is often less successful. Failed attempts with alternative medications can compound feelings of hopelessness in depressed patients. This underscores the importance of exploring alternative and innovative treatment options.

Revolutionizing Depression Treatment: Bloom Unlocks New Hope

At Bloom Health Centers, we prioritize providing innovative and effective solutions for those dealing with depression. Taking into consideration that every person’s experience with depression is unique, we design tailored treatments that satisfy the individual needs of each patient. Among the classical approaches such as medication and therapy, we offer two cutting-edge techniques for depression: Spravato® Esketamine Therapy and Transcranial Magnetic Stimulation (TMS).

In an interview, Dr. Yusuf Azim, Medical Director of Ancillary Services at Bloom Health Centers, revealed how these treatments work, their benefits, and potential side effects, highlighting Bloom’s determination to revolutionize the approach to depression treatment. If you are unfamiliar with these innovative treatment options, read further to learn more about Spravato® and TMS Therapy at Bloom Health Centers.


What is Spravato® Esketamine Therapy? Understanding the Treatment and Patient Eligibility

Spravato® Esketamine Therapy is an advanced, specially-made medication for depression that is taken via a nasal spray. Approved by the FDA, it is meant for individuals aged 18 years and over that have been diagnosed with MDD and have failed to respond to two or more antidepressants. As traditional antidepressants target serotonin and norepinephrine in the brain, this neuro drug acts on glutamate, which plays a key role in regulating mood. Since glutamate is an excitatory neurotransmitter, the increased glutamate activity begins exciting cells in the brain and throughout the central nervous system, which encourages learning functions, boosts your memory, and trains the brain to become comfortable with this new state, which helps to battle the symptoms of depression.

What happens during Spravato® treatment sessions?

Spravato® is taken in a Bloom clinic in a comfortable, private room where the patient is under constant supervision by medical professionals. The medication is administered twice a week over 8 to 12 sessions, with visible results appearing as soon as 24 hours after taking it, which has never been the case for any other antidepressant. It is important to note that Spravato® Esketamine is not a standalone treatment for depression; rather, it is used alongside an antidepressant.

Are there side effects to Spravato®?

Spravato® is safe and generally well-tolerated. Possible side effects can include temporary sedation, increased blood pressure, and dissociation. These side effects are transient and non-life threatening. Patients are advised not to drive home or operate machinery and to avoid returning to work until the following day after a good night’s sleep.

Want to find out if Spravato is right for you? Take the Spravato® Assessment

At Bloom Health Centers, we strive to revolutionize the way we treat depression. There is no one-size-fits-all approach, and with advanced and personalized plans, our patients can benefit from cutting-edge treatments such as Spravato® Esketamine Therapy or non-invasive treatments such as Transcranial Magnetic Stimulation (TMS).


What is TMS? Discover the benefits, potential side effects, and eligibility.

Transcranial Magnetic Stimulation (TMS) is an effective outpatient therapy option for those aged 18 and above diagnosed with major depressive disorder (MDD). Non-invasive, non-surgical, and safe, this treatment is administered without anesthesia. Ever since it received its FDA clearance in 2008, TMS has had an impactful role in treating depression.

How does TMS work?

Using a computer and stimulator, magnetic pulses are transmitted to parts of the brain affected by depression, helping to raise levels of hormones such as serotonin, epinephrine, and dopamine. Depending on the severity of the depression, the magnetic stimulation may be administered on either the left or right, or both sides, of the frontal lobe.

Are there side effects to TMS treatment?

TMS is considered an alternative to medication, with reduced risks of general body side effects. While some patients may experience temporary site stimulation discomfort (forehead) or headaches, these side effects are typically treatable and go away quickly.

The Science Behind TMS

It is believed that depression may result from an asymmetry in the functioning of the left and right sides of the brain, where the left is generally hypoactive and the right is hyperactive. By connecting to the limbic system – otherwise known as the depression circuit – TMS is an especially successful treatment. A clinical study conducted by Sackeim et al. (2020) has also shown that, through routine practice, TMS can provide significant benefits to those with MDD. As it is evidence-based and has a proven track record, TMS is suggested as the primary option to be considered.

The TMS procedure utilizes a computer and stimulator that releases pulses via a device on the patient’s forehead. They remain seated in a comfortable chair during the session. TMS not only eliminates many general side effects associated with taking medications but it can also be employed independently or in combination with other therapies.

Providing Top-Notch TMS Treatment

Bloom utilizes the FDA-approved NeuroStar TMS system, boasting the most extensive clinical data set among TMS systems for depression. The patient will sit in a pleasant chair with a cushioned apparatus with the magnetic pulse coil placed against their head. Insurance plans, including Medicare, usually cover the transcranial magnetic stimulation cost, so more than 300 million people can access this therapy. Patients can go back to their normal activities post-treatment. The transformation brought about by TMS is often dramatic.

Want to find out if TMS is right for you? Take the TMS Assessment

At Bloom, we understand that depression can be a challenging and isolating experience. We are here to show you that you are not alone. We will provide you with tailored assistance to find a plan that suits your individual needs. With a range of treatments – including Spravato® Esketamine, TMS, and conventional medicines – we aim to give you the most effective methods backed by scientific research. Moreover, we prioritize your comfort and well-being at all times.

It is possible to reclaim your quality of life through proper treatment and support. The Bloom Team is happy to provide you with compassionate guidance every step of the way.

Have questions?

We’re here to talk to you about your specific mental health needs. Give us a call or request an appointment through our online form.